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In 1995, tramadol was initially endorsed by the U.S. Sustenance and Drug Administration (FDA) as a non-controlled pain relieving. Nonetheless, since 1995, changes to the controlled substance status of tramadol have been made because of reports of medication misuse and redirection. The Drug Abuse Warning Network (DAWN) announced that around 20,000 crisis office visits were identified with tramadol non-therapeutic use in 2011. As indicated by the National Survey on Drug Use and Health (NSDUH) in 2012, 3.2 million individuals in the U.S. matured 12 or more established utilized tramadol for nonmedical purposes.
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